Raluca Budiu-Predoiu
Director, Precision Medicine Abbvie
Experienced and successful leader of precision medicine in early and late stages of clinical development, across multiple treatment modalities (small molecules, ADCs, monoclonal antibodies, CAR-T cells and vaccines) and therapeutic areas (oncology, immune-oncology, autoimmunity). Expertise in implementing global companion diagnostics for patient selection across the continuum of drug development. Recognized leader in the clinical biomarker space, successfully integrating pre-clinical and clinical biomarker work to inform on dose selection, drug combinations, indications selection for first in human studies, patient selection and differentiation from competitors.
Seminars
- Where can methylation-based liquid biopsy create tangible impact in drug development today?
- Can methylation enable earlier and more confident clinical trial decision-making?
- What must happen for methylation to become embedded in mainstream clinical trial design?
Moderated by:
- ctDNA as a predictive marker for therapeutic response and a potential surrogate for survival outcomes, enabling faster, more efficient trial designs
- ctDNA as an early, sensitive marker for tracking tumor burden and minimal residual disease (MRD), allowing for earlier intervention and better monitoring of disease progression
- Longitudinal ctDNA analysis for determining biologically active dosages, allowing for adjustments in dosage regimens to maximize efficacy while minimizing toxicity